Yes, you can get a bigger refund (not return) then what you pay in, but it depends on your situation. If you pay too much in, that's when you get a refund. You don't automatically get what you paid in... there are taxes for a reason. If you qualify for the child tax credit or EIC - those are credits that will give you a refund.
There are a FEW refundable credits.
1. Earned income credit. Requires very low earned income or low income plus qualifying children.
2. Additional Child tax credit. Requires earned income and a child under 17.
3. (New) The education credit. Requires you paid tuition.
4. Making Work Pay credit. This is based on earned income between $6451 and $75000. Most of us got the $400 in our paychecks, so unless we were self-employed, it won't get us more at tax time.
5. First time homebuyer's credit. Requires you to buy a house. The IRS is auditing all of these due the degree of fraud.
If you are eligible for a refundable credit like EIC, ACTC or the first time homebuyers credit it's possible to get more than what you paid in, otherwise no.
If you have low earned income and dependents, you may be entitled to additional refunds
the various credits you might be entitled to could result in a refund larger than what you had withheld